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Phytoene desaturase (neurosporene-forming)

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Phytoene desaturase (neurosporene-forming)
Identifiers
EC no.1.3.99.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Phytoene desaturase (neurosporene-forming) (EC 1.3.99.28, 3-step phytoene desaturase, three-step phytoene desaturase, phytoene desaturase (ambiguous), CrtI (ambiguous)) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming).[1][2] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 3 acceptor all-trans-neurosporene + 3 reduced acceptor (overall reaction)
(1a) 15-cis-phytoene + acceptor all-trans-phytofluene + reduced acceptor
(1b) all-trans-phytofluene + acceptor all-trans-zeta-carotene + reduced acceptor
(1c) all-trans-zeta-carotene + acceptor all-trans-neurosporene + reduced acceptor

This enzyme is involved in carotenoid biosynthesis.

See also

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References

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  1. ^ Raisig A, Bartley G, Scolnik P, Sandmann G (March 1996). "Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli". Journal of Biochemistry. 119 (3): 559–64. doi:10.1093/oxfordjournals.jbchem.a021278. PMID 8830054.
  2. ^ Wang CW, Liao JC (November 2001). "Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution". The Journal of Biological Chemistry. 276 (44): 41161–4. doi:10.1074/jbc.M105786200. PMID 11526111.
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